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The Nijmegen Biomedical Study, which assessed the relationship between fatigue and serum TSH, FT 4, and TPOAbs in 5897 participants, showed that subjects with a history of thyroid disease experienced more fatigue than the general population despite the normal TSH and FT 4 values ().

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An increase in dosage of l-T 4 may be necessary in athyreotic patients who are treated with TKIs; therefore, a careful follow-up is necessary during treatment with these drugs ().

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Las tasas tanto de los rechazos agudos como de la intensidad del rechazo agudo fueron ms bajas, asegur el autor principal del estudio, el Dr.

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Thyroid dysfunction due to increased thyroid autoimmunity may develop in patients receiving long-term treatment with cytokines for their cytotoxic effects.

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In the study by Rotondi et al (), preconception TSH levels in the lower quartile of the reference range during l-T 4 therapy were associated with an adequate TSH level at the first evaluation during pregnancy.

In a small nonrandomized study involving 11 hypothyroid patients who had been receiving a stable dose of l-T 4 each morning, a decrease in mean TSH and an increase in FT 4 levels was noted after bedtime administration of l-T 4 compared with the same l-T 4 dose taken in the morning ().

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