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Poor adherence has a negative effect on osteoporosis treatment outcomes including lower gains in bone mineral density (BMD), smaller decreases in the rate of bone turnover and a significantly greater risk of fractures.

Any one of these adverse side effects can be a sign of a serious underlying health issue if it is not a simply allergy to the medication itself.

Recent concerns have prompted regulatory agencies to review the safety of antiresorptive drugs for osteoporosis, while these same concerns among patients and physicians are decreasing the use of this particular class of drugs.

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Supplements for calcium, magnesium, and iron, antacids, or other products that contain aluminum can reduce the absorption of Ibandronate.

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Biphosphonates are a class of medicines used to treat or prevent osteoporosis, Paget's disease, and bone-related cancers.

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Women with a history of spinal fracture or with an existing fracture also are most likely to benefit from long-term use of the drugs, the researchers concluded.

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Together, osteoporosis and osteopenia are expected to affect an estimated 52 million women and men age 50 and older by 2010, and 61 million by 2020.

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