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Nineteen antiretroviral drugs have been approved for the treatment of HIV-1 infection: one nucleotide and seven nucleoside reverse transcriptase inhibitors (NRTIs), seven protease inhibitors (PIs), three nonnucleoside RT inhibitors (NNRTIs), and one fusion inhibitor.

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In one embodiment of the present invention, the esterification of Tenofovir monohydrate is carried out in the presence of a base and Wittig reagent, wherein base is selected from organic amine like trialkyl amine such as triethylamine, diisopropyl ethyl amine preferably triethylamine and the wittig reagent is selected from the group comprising Isopropyl triphenylphosphonium iodide, triphenylphosphonium bromide, n-propyl triphenyl phosphonium bromide, -propyl triphenyl phosphonium iodide, ethyl triphenylphosphonium iodide, ethyl triphenylphosphonium bromide, tert-butyl triphenylphosphonium iodide, tert-butyl triphenylphosphonium bromide.

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The goal of HAART is to reduce the amount of virus in your body, or the viral load, to a level that can no longer be detected with blood tests.

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