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The New England Journal of Medicine editorialized in 2000: "With these recent careful and precise observations in blind persons, the true potential of melatonin is becoming evident, and the importance of the timing of treatment is becoming clear.

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Melatonin (N-acetyl-5-methoxytryptamine) is secreted during the dark hours at night by pineal gland, and it regulates a variety of important central and peripheral actions related to circadian rhythms and reproduction.

Los hallazgos responden a una pregunta significativa: de qu forma los relojes biolgicos controlan la actividad de las neuronas reloj, que a su vez regulan los ritmos conductuales, seal en un comunicado de prensa de la Universidad de Nueva York el autor principal del estudio Justin Blau, profesor asociado del departamento de biologa de la universidad.

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Melatonin is sometimes used to mitigate the side effects of chemotherapy including weight loss, nerve pain, weakness and a condition called thrombocytopenia.

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We are currently testing this hypothesis by determining whether interventions designed to prevent phase shifts in nocturnal melatonin secretion have therapeutic effects in rapid-cycling bipolar patients.

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