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Albendazole (ALB) is a typical, broad spectrum benzimidazole antiparasitic agent, first approved for human use in 1982.

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Although generally well-tolerated, the following adverse reactions were reported in the first phase of WHO-coordinated studies1 involving 30 patients given high-dose therapy with albendazole for the treatment of cystic echinococcosis (hydatid disease): raised serum-transaminase levels (2 patients), reduced leucocyte counts (1 patient), gastrointestinal symptoms (1 patient), allergic conditions (1 patient), and loss of hair (1 patient).

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To inhibit CYP3A4 isozyme-related ABZSX degradation, albendazole was coadministered with cimetidine.

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