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In some cases, hyperglycemia has resolved when the atypical antipsychotic was discontinued; however, some patients required continuation of anti-diabetic treatment despite discontinuation of the suspect drug.
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The effects of oral paliperidone on the QT interval were evaluated in a double-blind, active-controlled (moxifloxacin 400 mg single dose), multicenter QT study in adults with schizophrenia and schizoaffective disorder, and in three placebo- and active-controlled 6-week, fixed-dose efficacy trials in adults with schizophrenia.
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Results of the systematic review of the literature are presented in this manuscript in brief; readers interested in the full analysis and discussion of the systematic review findings are referred to a separate manuscript by Pringsheim ().
When data on medication side effects were unavailable from clinical trials or prospective cohort studies, we searched for data from retrospective cohort studies, case series, case reports or drug surveillance programs.
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