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The Spanish were aware of the medicinal properties of cinchona bark by the 1570s or earlier: (1571) and Juan Fragoso (1572) both described a tree that was subsequently identified as the cinchona tree and whose bark was used to produce a drink to treat diarrhea.
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Tonic water infused with very small quantity of naturally derived quinine offers a bitter-sweet flavor that your taste buds will surely remember for a very long time.
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The legend of quinine's discovery accepted in Europe differs though, and involves the Spanish Countess of Chinchon who, while in Peru, contracted a fever that was cured by the bark of a tree.
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Countess of Chichon became the first on record to receive quinine.
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More research is needed to clarify the best dose and duration of treatment, as well as alternatives to quinine for cramps.
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