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We estimate that use of paroxetine for 41% of tamoxifen treatment (the median overlap in our sample) would result in one additional breast cancer death within 5 years of cessation of tamoxifen for every 19.
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The molecular mechanisms that explain the improved prognosis in hereditary BRCA-associated ovarian cancer are unknown but may be related to the function of BRCA genes.
Additional value of the 70-gene signature and levels of ER and PR for the prediction of outcome in tamoxifen-treated ER-positive breast cancer.
Limitations of the present study are that the correlations observed are weak and we have not had admittance to patient journals and do not know of any additional drug use.
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Compared with tamoxifen, aromatase inhibitors (AIs) such as anastrozole, letrozole, and exemestane show increased disease-free survival benefits; they have therefore become the standard of care for adjuvant endocrine treatment of postmenopausal women with hormone receptor - positive early breast cancer ().
Here, we examined relationships between the serum levels of tamoxifen, estrogens, follicle-stimulating hormone (FSH), and sex hormone-binding globulin (SHBG) in postmenopausal breast cancer patients.
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After a 3-month placebo washout, participants were then crossed over to the alternate treatment and repeated the drug challenges after 3 months.
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Table 1 Meta-Analysis of Trials of Adjuvant Tamoxifen Therapy in Women with Breast Cancer, According to Estrogen-Receptor Status and Duration of Therapy.
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Despite the initial enthusiasm over the use of transplantation therapy for treatment of high risk breast cancer, this approach is no longer generally recommended and is rarely used outside of a clinical trial setting.
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There are limited data on the efficacy of tamoxifen for breast cancer risk reduction in BRCA1 and BRCA2 mutation carriers.
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HDL (high density lipoprotein, commonly referred to as "good cholesterol") helps to protect the arteries by bringing unused cholesterol to the liver where it is broken down.
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There are no data suggesting that combination therapy results in an OS benefit over single-agent therapy.
Serum tamoxifen concentrations vary widely from patient to patient.
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Fisher B, Costantino J, Redmond C, et al: A randomized clinical trial evaluating tamoxifen in the treatment of patients with node- negative breast cancer who have estrogen-receptor-positive tumors.
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Slightly detrimental effects on well-being and several decision-related outcomes, however, were noted among affected women.
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