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This medication worked for my first acute gout flare, although I was prescribed a low dose 0.3 twice a day because of it's toxic property. Later I discovered 1.2 for first dose then 0.6 an hour later then prophylactic use until flare up was under control. The side effects where mainly bowl related. It was probably a good idea to start with a low dose, but did not get relief until I had to start the dose over with 1.2 then 0.6.
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Blood samples will be drawn from all participants before dosing and for 24 hours post-dose on a confined basis at times sufficient to adequately define the pharmacokinetics of colchicine.
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Ice applied to the affected joint is also helpful.
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Gout can progress with or without acute inflammatory responses during intercritical periods.
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