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In one case, neonatal plasma clozapine concentrations were found to be twice that found in maternal plasma.

Descriptive statistics and statistical test were used to show similarity and equilibrium between the treatment groups and their characteristics at baseline.

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The results of a multi-centre audit of the prescribing of antipsychotic drugs for in-patients in the UK.

This type of sleep disturbance may be associated with a greater susceptibility to medication-induced hallucinations as well as excessive daytime sleepiness.

Only your doctor, nurse or pharmacist can provide you with advice on what is safe and effective for you.

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Rationale (see below) into the system and change a patient's Treatment Status back to Active.

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Behavioural means such as the withdrawal of positive reinforcement (leave periods or access to cigarettes) are available, although treating teams may be reluctant to enforce them.

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Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis.

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Many reasons for clozapine underuse are cited: insufficient prescriber training; clinical concern over rare but serious medical risks, including agranulocytosis and myocarditis; frequent blood draws for granulocyte monitoring; relatively high administrative burden; and troublesome side effects, including weight gain, sedation, and drooling ().

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If conditions warrant abrupt discontinuation (eg, severe neutropenia), monitor patient for psychosis and cholinergic rebound (eg, headache, nausea, vomiting, diarrhea, profuse diaphoresis).

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Patients who are having a first episode of psychosis are both more responsive to these medicines and are more sensitive to adverse effects.

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