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The Imatinib mesylate of claim 9, wherein the propanol is selected from the group consisting of: n-propanol and isopropanol; the butanol is selected from the group consisting of: n-butanol, isobutanol, sec-Butanol, tert-Butanol; and the pentanol is selected from the group consisting of: n-pentanol, isopentanol and sec-pentanol.

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This patient information sheet applies only to approved uses of the drug.

Gastrointestinal lymphadenopathy can be symptomatic due to mass effect and inflammation of the bowel wall.

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The role of SCT as second- or third-line treatment in chronic phase CML is further assisted by the recently published results of the German CML III study.

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The patient was treated with acyclovir for 14 days, and repeat endoscopy for a repeat episode of hematemesis did not reveal any further evidence of herpetic gastritis on biopsy.

previous data suggest that the response of chronic myeloid leukemia cells to imatinib is dose

Imatinib blocks the activity of an enzyme known as tyrosine kinase, which delivers a signal that causes cells to multiply.

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We used a biotinylated active site-directed probe, which covalently binds to the proteasomally active beta-subunits in an activity-dependent fashion.

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Talpaz et al reported that among 235 patients with accelerated-phase CML, treatment with imatinib yielded a hematologic response in 82% of patients (sustained in 69% and complete in 34%) and major cytogenetic response in 24% (complete in 17%).

To better assess durability of response to and tolerability of dasatinib, data from a 2-year minimum follow-up for a dose-optimization study in chronic-phase chronic myeloid leukemia are reported here.

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The results of patients treated for AP fall between those observed in myeloid BC and CP with the 1-year survival achieved in 74% patients.

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Unfortunately, only a small fraction of patients are eligible for surgical resection with disappointing 5-year survival rates of 67% and 23% for stage IA and stage IIIA, respectively.

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However, interferon alfa plus low-dose cytarabine requires regular subcutaneous injections of two drugs, and side effects are frequent and troublesome.

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Imatinib is a substrate of the human organic cation transporter 1 (hOCT1), but not for hOCT2 or hOCT3 ().

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We will continue to follow the patients in this study to evaluate the long-term tolerability of imatinib and the durability of responses and to determine whether the leukemia can be eradicated at the molecular level.

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The most common etiology of hyperthyroidism, Grave's disease, is an autoimmune disorder; antibodies directed against TSH receptors on the thyroid gland increase thyroid hormone synthesis and gland size.

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However, valid long term survival comparisons between allogeneic SCT and non-transplant second line treatment approaches post-imatinib failure are not available at the moment.

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This case represents a rare cause of a treatable bacterial infection in a transplant patient and the value of social and personal history in medical management.

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No overall differences in effectiveness were observed between younger and older patients.

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