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Des études isolées n'ont rapporté aucune différence dans la réduction de la douleur quand l'allopurinol (300 mg par jour) a été comparé à un placebo sur 10 jours, et aucune différence dans la régression des tophus quand l'allopurinol (200 à 300 mg par jour) a été comparé au fébuxostat (80 mg par jour).

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This summary of a Cochrane review presents what we know from research about the effect of allopurinol compared with placebo or other treatments that reduce uric acid levels in treating people with chronic gout.

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These tables provide key information concerning the quality of evidence, the magnitude of effect of the interventions examined and the sum of available data on our seven main outcomes (participant-reported reduction in acute gout attack frequency, proportion of participants achieving a target serum urate level, joint pain reduction, function, tophus regression, number of study participant withdrawals due to AEs and SAEs), as recommended by The Cochrane Collaboration ().

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