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Other Uses For This Medicine The good thing about preventing seizures may outweigh any risks posed by taking divalproex sodium. There could divalproex also be other seizure medicines that may be more safely used throughout being pregnant. Divalproex mail order work. Among 6 breast-feeding moms who took valproate 750 mg/day or 1,000 mg/day for bipolar dysfunction, toddler serum concentrations ranged from zero.7 mcg/mL to divalproex 1.5 mcg/mL.Adverse developmental or cognitive defects were not noticed in children up to 6 years of age after publicity to valproate by way of breast milk.The thrombocytopenia and anemia resolved approximately a month after the mother discontinued breast-feeding.Infant publicity was 0.9% to 2.three% of therapeutic maternal serum concentrations. Depakote Precautions Several hypotheses have been proposed in regards to the mechanism of action in epilepsy and bipolar dysfunction. The most well studied and understood mechanism of valproate is its ability to potentiate or mimic the effects of the inhibitory neurotransmitter, gamma-aminobutyric acid (Loscher 2002; Casey et al 2003; Salloum et al 2005). Indirectly, this potentiation of GABA has been hypothesized to supply inhibitory effects on central dopamine (Casey et al 2002; Loscher 2002). Some of the other and fewer properly understood mechanisms involve the inhibition of neuronal excitability and a resultant anti-kindling impact .

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